5/26/2023 0 Comments Stem cell treatment jointsThat treatment has become an approved cell therapy, which thousands of patients have received. In the early 1990s, he and his colleagues began treating patients with cartilage damage with the patient’s own cells. In this way we hope to produce a universal donor for osteoarthritis patients.” Inflammatory diseaseĪnders Lindahl, a professor at the University of Gothenburg and senior researcher in the EU project AutoCRAT, was one of the first in the world to start working with cell therapy. For many years, we have developed new protocols where we differentiate IPS cells to become chondrocytes. We cultivate cartilage cells and examine their extracellular vesicles. We assist the AutoCRAT project by providing cartilage cells that the end product can be compared with. “Our research team in Gothenburg has extensive clinical experience of cell therapy and has long been repairing cartilage. They act as messengers between cells and may control the growth of cartilage cells or reduce inflammation in joints. These vesicles are small spheres of biological information that separate from the surface of the cell. The third track concerns what are known as extracellular vesicles. These cells can then be reprogrammed into cartilage cells, which can provide large amounts of cells that could serve the need of many patients. Another track is induced pluripotent stem cells, IPS, which is a method of inducing adult cells to become stem cells again. The first option being investigated in the EU project is mesenchymal stem cells, a type of adult stem cell taken from adipose tissue or bone marrow. Soon we need to agree within the project on which alternative is most likely to become a cell therapy for osteoarthritis, which we will test next year in a large animal model.” “In AutoCRAT we develop new stem cell-based products, all of which have the potential to become a future treatment. Kristina Vukusic, a researcher at the University of Gothenburg, heads the Swedish part of the EU project.
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